Publications – University of Copenhagen

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Panum NMR Core Facility > Publications



Cerebrospinal and Interstitial Fluid Transport via the Glymphatic Pathway Modeled by Optimal Mass Transport. Vadim Ratner, Ph.D.; Yi Gao, Ph.D.; Hedok Lee, Ph.D.; Rena Elkin, B.A.; Maiken Nedergaard, M.D.; Helene Benveniste, M.D. Allen Tannenbaum. NeuroImage 2017 (in press):

Quantitative 3D T1 mapping technique in rat brain using VFA-FLASH at 9.4T.  Hedok Lee, Simon Sanggaard, Kristian Nygaard Mortensen, Palle Koch, Maiken Nedergaard, and Helene Benveniste, ISMRM 25th Annual Meeting & Exhibition 2017

3D DCE-MR imaging shows compromised brain waste transport in spontaneously hypertensive rats. Kristian Nygaard Mortensen, Simon Sanggaard, Hedok Lee, Palle Koch, Maiken Nedergaard, Bjørn Quistorff, and Helene Benveniste, ISMRM 25th Annual Meeting & Exhibition 2017

In vivo changes in neurotransmitter and metabolite levels following selective activation of the nigrostriatal dopaminergic pathway. Simone Baerentzen, Agata Casado, Elina L’Estrade, Fraser G Edgar, Celia Kjaerby, Hedok Lee, Helene Benveniste, Matthias Herth, Mikael Palner. BRAIN & BRAIN PET 2017

Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. Hedok Lee, Kristian Mortensen, Simon Sangsgaard, Palle Koch, Hans Brünner, Bjørn Quistorff, Maiken Nedergaardand Helene Benveniste. Magnetic Resonance in Medicine 2017 (in press)

Ongoing Projects

Temporal profile of macrophage infiltration following brain infarction

Henrik Hasseldam (, Clara Munoz (, Olivia Lie-Andersen (

The aim of this project is to investigate the longitudinal infiltration of immune cells after focal brain ischemia. Tracking of immune cell migration from the periphery to the CNS facilitates direct correlations between immune cell activity, infarct development and clinical outcome. With the use fluorine-based tracers (V-sense, Celsense etc.), we are able to determine the migration kinetics of specific immune cell populations, which makes it possible to elucidate their effects on disease pathogenesis.

Behavioral Neuroimaging

Mikael Palner (, Simone Bærentzen (

We are interested in the functional responses of the brain to selective modulation of independent neuronal pathways. We use a combination of Designer Receptors Activated Exclusively by Designer Drugs (DREADDs), behavioral assessment and neuronal imaging by Positron Emission Tomography (PET), Magnetic Resonance Spectroscopy (MRS) and functional Magnetic Resonance Imaging (fMRI).

The role of the glymphatic system in small vessel disease

Simon Sanggaard (, Serhii Kostrikov (, Kristian Nygaard Mortensen (

Fifteen million people worldwide suffer dementia that is wholly or partly due to age-related small vessel disease (SVD) of the brain. Using dynamic contrast enhanced MRI to measure the ability of the brain to dispose of waste, we are screening several different mouse models of SVD for the involvement of the glymphatic system in the pathophysiology of SVD-related dementia.

Glymphatic impairment due to hypertension

Kristian Nygaard Mortensen (, Simon Sanggaard (, Serhii Kostrikov (

To examine the role of chronic hypertension in neurodegeneration, we are measuring how increased blood pressure impacts the ability of the brain to dispose of waste material and metabolites. We use dynamic contrast enhanced MRI to quantitatively track the movement of contrast agents through the cerebrospinal fluid (CSF), brain and periphery in normotensive compared to spontaneously hypertensive rats.

A very early window in Acute Myocardial Infarction using in vivo MR Imaging/Spectroscopy - A rat model

Henrik H. El Ali (

The aim of this project is to explore the possibility of monitoring the very early stage of what is going on when the heart is malfunctioning due to an inadequate blood supply to itself. Advanced MR imaging and spectroscopy technique is used to identify and characterize ischemic area and the metabolites of interest.

In vivo Longitudinal Measurements of NAA as a Neuronal Marker in MCAO Animal Model

Henrik H. El Ali (, Flemming Fryd Johansen and Henrik Hasseldam

Aim: In vivo measurements of the Metabolites concentration (NAA, tCho, tCr and Lac) in the mouse brain in range of 1-28 days after the ischemic infarct elicitation. Using in vivo MR Spectroscopy might provide quantitative indices, which may be useful for prognosis and therapeutic monitoring in order to have real clinical impact. (in Progress)