Publications / Presentations
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Publications
2024
| Jensen DB, Toft-Bertelsen TL, Barbuskaite D, Stubbe J, Nietzsche S, Capion T, Norager NH, Olsen MH, Sørensen AT, Dimke H, Hübner CA, Juhler M, MacAulay N | The Na+,K+,2Cl− Cotransporter, Not Aquaporin 1, Sustains Cerebrospinal Fluid Secretion While Controlling Brain K+ Homeostasis. Adv Sci 2024, e2409120. doi:10.1002/advs.202409120. |
| Gomolka RS | Automatic Adaptive Algorithm for Delineation of Cerebral-Spinal Fluid Regions for Non-contrast Magnetic Resonance Imaging Volumetry and Cisternography in Mice. Bio-protocol 2024, in press. doi:10.21769/BioProtoc.5148 |
| Asiminas A, Gomolka RS, Gregoriades S, Hirase H, Nedergaard M, Beinlich FRM | Protocol to study oxygen dynamics in the in vivo mouse brain using bioluminescence microscopy. STAR Protoc 2024. 5:103334. doi: 10.1016/j.xpro.2024.103334. |
| Plá V, Bitsika S, Giannetto MJ, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K | Response to Commentary on "Structural characterization of SLYM - a 4th meningeal membrane" by Julie Siegenthaler and Christer Betsholtz. Fluids Barriers CNS 2024. 21:70. doi:10.1186/s12987-024-00567-z |
| Kroesbergen E, Riesselmann LV, Gomolka RS, Plá V, Esmail T, Stenmo VH, Kovács ER, Nielsen ES, Goldman SA, Nedergaard M, Weikop P, Mori Y | Glymphatic clearance is enhanced during sleep. BioRxiv, doi: 10.1101/2024.08.24.609514 |
| Rasmussen MK, Møllgård K, Bork P, Weikop P, Esmail T, Drici L, Albrechtsen NJW, Carlsen JF, Huynh N, Ghitani N, Mann M, Goldman S, Mori Y, Chesler A, Nedergaard M | Trigeminal ganglion neurons are directly activated by influx of CSF solutes in a migraine model. Science 2024. 385:80-86. doi:10.1126/science.adl0544 |
| Mori Y, Hirase H | Emerging insights into cerebrospinal fluid dynamics and glial involvement therein. Jpn J Cell 2024. 56:579-583. |
| van Osch MJP, Wåhlin A, Scheyhing P, Mossige I, Hirschler L, Eklund A, Mogensen K, Gomolka R, Radbruch A, Qvarlander S, Decker A, Nedergaard M, Mori Y, Eide PK, Deike K, Ringstad G | Human brain clearance imaging: Pathways taken by magnetic resonance imaging contrast agents after administration in cerebrospinal fluid and blood. NMR Biomed 2024. 37:e5159. doi:10.1002/nbm.5159 |
| Plá V, Bitsika S, Giannetto MJ, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K | In response to "An "outer subarachnoid space": fact or artifact? A commentary on "Structural characterization of SLYM: a 4th meningeal membrane" fluids and barriers of the CNS (2023) 20:93 by V. Plá et al.". Fluids Barriers CNS 2024. 21:49. doi:10.1186/s12987-024-00540-w |
| Bork PAR, Hauglund NL, Mori Y, MøllgårdvK, Hjorth PG, Nedergaard M | Modeling of brain efflux: Constraints of brain surfaces. PNAS 2024. 121:e2318444121. doi:10.1073/pnas.2318444121 |
| Delle C, Wang X, Giannetto M, Newbold E, Peng W, Gomolka RS, Ladrón-de-Guevara A, Cankar N, Nielsen ES, Kjaerby C, Weikop P, Mori Y, Nedergaard M | Transient but not chronic hyperglycemia accelerates ocular glymphatic transport. Fluids Barriers CNS 2024. 21:26. doi:10.1186/s12987-024-00524-w |
| Giannetto MJ, GomolkaRS, Gahn-Martinez D, Newbold EJ, Bork PAR, Chang E, Gresser M, Thompson T, Mori Y, Nedergaard M | Glymphatic fluid transport is suppressed by the AQP4 inhibitor AER-271. Glia 2024. 72:982-998. doi:10.1002/glia.24515 |
| Wardman JH, Andreassen SN, Toft-Bertelsen TL, Jensen MN, Wilhjelm JE, Styrishave B, Hamann S, Heegaard S, Sinclair AJ, MacAulay N | CSF hyperdynamics in rats mimicking the obesity and androgen excess characteristic of patients with idiopathic intracranial hypertension. Fluids Barriers CNS 2024. 21:10. doi:10.1186/s12987-024-00511-1 |
| Agarwal N, Lewis LD, Hirschler L, Rivera LR, Naganawa S, Levendovszky SR, Ringstad G, Klarica M, Wardlaw J, Iadecola C, Hawkes C, Carare RO, Wells J, Bakker ENTP, Kurtcuoglu V, Bilston L, Nedergaard M, Mori Y, Stoodley M, Alperin N, de Leon M, van Osch MJP | Current Understanding of the Anatomy, Physiology, and Magnetic Resonance Imaging of Neurofluids: Update From the 2022 "ISMRM Imaging Neurofluids Study group" Workshop in Rome. J Magn Reson Imaging 2024. 59: 431-449. doi:10.1002/jmri.28759 |
2023
| Plá V, Bitsika S, Giannetto MJ, Ladron-de-Guevara A, Gahn-Martinez D, Mori Y, Nedergaard M, Møllgård K | Structural characterization of SLYM-a 4th meningeal membrane. Fluids Barriers CNS 2023. 20:93. doi: 10.1186/s12987-023-00500-w |
| Lolansen SD, Barbuskaite D, Ye F, Xiang J, Keep RF, MacAulay N | Spontaneously hypertensive rats can become hydrocephalic despite undisturbed secretion and drainage of cerebrospinal fluid. Fluids Barriers CNS 2023. 20:53. doi:10.1186/s12987-023-00448-x |
| Mathiesen BK, Miyakoshi LM, Cederroth CR, Tserga E, Versteegh C, Bork PAR, Hauglund NL, Gomolka RS, Mori Y, Edvall NK, Rouse S, Møllgård K, Holt JR, Nedergaard M, Canlon B | Delivery of gene therapy through a cerebrospinal fluid conduit to rescue hearing in adult mice. Sci Transl Med 2023. 15:eabq3916. doi:10.1126/scitranslmed.abq3916 |
| Christiansen LI, Ventura GC, Holmqvist B, Aasmul-Olsen K, Lindholm SEH, Lycas MD, Mori Y, Secher JB-M, Burrin DG, Thymann T, Sangild PT, Pankratova S | Insulin-like growth factor 1 supplementation supports motor coordination and affects myelination in preterm pigs. Front Neurosci 2023. 17:1205819. doi:10.3389/fnins.2023.1205819 |
| Delle C, Cankar N, Holgersson CD, Knudsen HH, Nielsen ES, Kjaerby C, Mori Y, Nedergaard M, Weikop P | Long-term high-fat diet increases glymphatic activity in the hypothalamus in mice. Sci Rep 2013. 13:4137. doi.org/10.1038/s41598-023-30630-y |
| Sigurdsson B, Hauglund NL, Lilius TO, Mogensen FLH, Mortensen KN, Beschorner N, Klinger L, Bærentzen SL, Rosenholm MP, Shalgunov V, Herth M, Mori Y, Nedergaard M | A SPECT-based method for dynamic imaging of the glymphatic system in rats. J Cereb Blood Flow Metabol 2023. 43:1153-1165. doi:10.1177/0271678X231156982 |
| Lilius TO, Mortensen KN, Deville C, Lohela TJ, Stæger FF, Sigurdsson B, Fiordaliso EM, Rosenholm M, Kamphuis C, Beekman FJ, Jensen AI, Nedergaard M | Glymphatic-assisted perivascular brain delivery of intrathecal small gold nanoparticles. J Control Release 2023. 355:135-148. doi:10.1016/j.jconrel.2023.01.054 |
| Gomolka RS, Hablitz LM, Mestre H, Giannetto M, Du T, Hauglund NL, Xie L, Peng W, Martinez PM, Nedergaard M, Mori Y | Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation. eLife 2023. 12:e82232 doi:10.7554/eLife.82232. |
| Kimura Y, Nakazawa S, Nishigori K, Mori Y, Ichihara J, Yoshioka Y | Ultra-high-field pharmacological functional MRI of dopamine D1 receptor-related interventions in anesthetized rats. Pharmacol Res Perspectives 2023, 11(2):e01055. doi:10.1002/prp2.1055 |
| Shalgunov V, van den Broek SL, Andersen IV, García-Vázquez R, Raval NR, Palner M, Mori Y, Schäfer G, Herrmann B, Mikula H, Beschorner N, Nedergaard M, Syvänen S, Barz M, KnudsenGM, Battisti UM, Herth MM |
Pretargeted Imaging beyond the Blood-Brain Barrier.RSC Med Chem 2023. 14:444-453. doi: 10.1039/D2MD00360K |
| Møllgård K, Beinlich FRM, Kusk P, Miyakoshi LM, Delle C, Plá V, Hauglund NL, Esmail T, Rasmussen MK, Gomolka RS, Mori Y, Nedergaard M | A mesothelium divides the subarachnoid space into functional compartments. Science 2023, 379(6627):84-88. doi:10.1126/science.adc8810 |
2022
| Liu G, Ladrón-de-Guevara A, Izhiman Y, Nedergaard M, Du T | Measurements of cerebrospinal fluid production: a review of the limitations and advantages of current methodologies. Fluids Barriers CNS 2022, 19:101. doi:10.1186/s12987-022-00382-4 |
| Liu R, Lauze FB, Erleben K, Berg RW, Darkner S | Bundle geodesic convolutional neural network for diffusion-weighted imaging segmentation. J Med Imaging 2022, 9:064002. doi: 10.1117/1.JMI.9.6.064002 |
| Lilius TO, Rosenholm M, Klinger L, Mortensen KN, Sigurdsson B, Mogensen FLH, Hauglund NL, Nielsen MSN, Rantamäki T, Nedergaard M | SPECT/CT imaging reveals CNS-wide modulation of glymphatic cerebrospinal fluid flow by systemic hypertonic saline. iScience 2022. doi:10.1016/j.isci.2022.105250 |
| Lolansen SD, Andreassen SN, Rostgaard N, Olsen MH, Norager NH, Capion T, Rath MF, Juhler M, MacAulay N | Lysophosphatidic acid as a CSF lipid in posthemorrhagic hydrocephalus that drives CSF accumulation via TRPV4-induced hyperactivation of NKCC1. Fluids Barriers CNS 2022, 19:69. doi:10.1186/s12987-022-00361-9 |
| Kelley DH, Bohr T, Hjorth PG, Holst SC, Hrabětová S, Kiviniemi V, Lilius T, Lundgaard I, Mardal K-A, Martens EA, Mori Y, Nägerl UV, Nicholson C, Tannenbaum A, Thomas JH, Tithof J, Benveniste H, Iliff JJ, Nedergaard M | The glymphatic system: Current understanding and modeling. iScience 2022, doi:10.1016/j.isci.2022.104987. |
| Baerends E, Soud K, Folke J, Pedersen A-K, Henmar S, Konrad L, Lycas MD, Mori Y, Pakkenberg B, Woldbye DPD, Dmytriyeva O, PankratovaS | Modeling the early stages of Alzheimer’s disease by administering intracerebroventricular injections of human native Aβ oligomers to rats. Acta Neuropathologica Comm 2022, 10:113. doi:10.1186/s40478-022-01417-5. |
| Lolansen SD, Rostgaard N, Barbuskaite D, Capion T, Olsen MH, Norager NH, Vilhardt F, Andreassen SN, Toft-Bertelsen TL, Ye F, Juhler M, Keep RF, MacAulay N | Posthemorrhagic hydrocephalus associates with elevated inflammation and CSF hypersecretion via activation of choroidal transporters. Fluids Barriers CNS 2022, 19:62. doi:10.1186/s12987-022-00360-w. |
| Andersen C, Uvebrant K, Mori Y, Aarsvold S, Jacobsen S, Berg LC, Lundgren‑Åkerlund E, Lindegaard C | Human integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee and assume a chondrocyte-like phenotype. Stem Cell Res Ther 2022. 13:206. doi:10.1186/s13287-022-02884-2. |
| Andersen C, Griffin JF, Jacobsen S, Østergaard S, Walters M, Mori Y, Lindegaard C | Validation of ultrasonography for measurement of cartilage thickness in the equine carpus. Vet Radiol Ultrasound 2022, 63:478-489. doi:10.1111/vru.13085. |
| Henriksen NL, Asmussen KS, Pan X, Jiang P, Mori Y, Christiansen LI, Sprenger RR, Ejsing CS, Pankratova S, Thymann T | Brain lipidomics and neurodevelopmental outcomes in intrauterine growth restricted piglets fed dairy or vegetable fat diets. Sci Rep 2022, 12:3303. doi:10.1038/s41598-022-07133-3. |
| Du T, Mestre H, Kress BT, Liu G, Sweeney AM, Samson AJ, Rasmussen MK, Mortensen KN, Bork PAR, Peng W, Olveda GE, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Hirase H, Mori Y, Nedergaard M |
Cerebrospinal fluid is a significant fluid source for anoxic cerebral oedema. Brain 2022, 145:787-797, doi:10.1093/brain/awab293 |
2021
| Liu Y, Bergmann T, Mori Y, Vidal JMP, Pihl M, Vasistha N, Thomsen PD, Seemann SE, Gorodkin J, Hyttel P, Khodosevich K, Witter MP, Hall VJ |
Development of the entorhinal cortex occurs via parallel lamination during neurogenesis. Front Neuroanat 2021, 15:663667, doi:10.3389/fnana.2021.663667 |
| Andersen C, Uvebrant K, Aarsvold S, Jacobsen S, Berg LC, Lundgren-Åkerlund E, Mori Y, Lindegaard C |
Integrin α10β1-selected mesenchymal stem cells home to cartilage defects in the rabbit knee after intra-articular injection. Osteoarthritis and Cartilage 2021, 29:S403-S404. doi:10.1016/j.joca.2021.02.522 |
| Henriksen NL, Aasmul-Olsen K, Venkatasubramanian R, Nygaard MKE, Sprenger RR, Heckmann AB, Ostenfeld MS, Ejsing CS, Eskildsen SF, Müllertz A, Sangild PT, Bering SB, Thymann T | Dairy-Derived Emulsifiers in Infant Formula Show Marginal Effects on the Plasma Lipid Profile and Brain Structure in Preterm Piglets Relative to Soy Lecithin. Nutrients 2021, 13(3):718. doi:10.3390/nu13030718 |
| Mestre H, Du T, Nedergaard M, Mori Y | Diffusion-weighted MRI protocol for acute brain edema detection after middle cerebral artery occlusion in mice. Bio-protocol 2021, epub. bio-protocol.org/prep750 |
| Stanton EH, Persson NDÅ, Gomolka RS, Lilius T, Sigurdsson B, Lee H, Xavier ALR, Benveniste H, Nedergaard M, Mori Y | Mapping of CSF Transport Using High Spatiotemporal Resolution Dynamic Contrast-enhanced MR Imaging in Mice: Effect of Anesthesia. Magn Reson Med 2021, 85(6):3326-3342. doi:10.1002/mrm.28645 |
2020
| Goldman N, Hablitz LM, Mori Y, Nedergaard M | The Glymphatic System and Pain. Med Acupunct 2020, 32(6):373-376. doi:10.1089/acu.2020.1489 |
| Henmar S, Simonsen EB, Berg RW | What are the gray and white matter volumes of the human spinal cord? J Neurophysiol 2020 124(6):1792-1797. doi: 10.1152/jn.00413.2020 |
| Andersen SB, Taghavi I, Hoyos CAV, Søgaard SB, Gran F, Lönn L, Hansen KL, Jensen JA, Nielsen MB, Sørensen CM | Super-Resolution Imaging with Ultrasound for Visualization of the Renal Microvasculature in Rats Before and After Renal Ischemia: A Pilot Study. Diagnostics 2020, 10(11):862. doi:10.3390/diagnostics10110862 |
| Mestre H, Mori Y, Nedergaard M. |
The Brain’s Glymphatic System: Current Controversies. Trends in Neurosciences 2020, 43(7):458-466. doi:10.1016/j.tins.2020.04.003 |
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Fujiwara S, Mori Y, de la Mora DM, Akamatsu Y, Yoshida K, Shibata Y, Masuda T, Ogasawara K, Yoshioka Y |
Feasibility of IVIM parameters from diffusion-weighted imaging at 11.7T MRI for detecting ischemic changes in common carotid artery occlusion rats. Sci Rep 2020, 10:8404. doi://10.1038/s41598-020-65310-8 |
| Mestre H, Du T, Sweeney AM, Liu G, Samson AJ, Peng W, Mortensen KN, Stæger FF, Bork PAR, Bashford L, Toro ER, Tithof J, Kelley DH, Thomas JH, Hjorth PG, Martens EA, Mehta RI, Solis O, Blinder P, Kleinfeld D, Hirase H, Mori Y, Nedergaard M |
Cerebrospinal fluid influx drives acute ischemic tissue swelling. Science 2020, 367(6483):eaax7171. doi://10.1126/science.aax7171. |
2019
| Thakur A, Rose F, Ansari SR, Koch P, Martini V, Ovesen SL, Quistorff B, Maritim S, Hyder F, Andersen P, Christensen D, Mori Y, Foged C | Design of gadoteridol-loaded cationic liposomal adjuvant CAF01 for MRI of lung deposition of intrapulmonary administered particles. Mol Pharm 2019, 16(11):4725-4737. doi: 10.1021/acs.molpharmaceut.9b00908. |
| Liu Y, Bergmann T, Lee J, Pfisterer U, Handfield LF, Mori Y, Asenjo-Martinez A, Lisa-Vargas I, Seemann SE, Lee JTH, Patikis N, Vidal JMP, Pihl M, Kornum BR, Thomsen PD, Hyttel P, Witter MP, Khodosevich K, Gorodkin J, Hemberg M, Pers T, Hall VJ | Sandwich cortical lamination and single-cell analysis decodes the developing spatial processing system. doi: 10.1101/738443 |
| Nygaard Mortensen K, Sanggaard S, Mestre H, Lee H, Kostrikov S, Xavier ALR, Gjedde A, Benveniste H, Nedergaard M | Impaired Glymphatic Transport in Spontaneously Hypertensive Rats. J Neurosci 2019, . doi: 10.1523/JNEUROSCI.1974-18.2019 |
| Koundal S, Liu X, Sanggaard S, Mortensen K, Wardlaw J, Nedergaard M, Benveniste H, Lee H | Brain Morphometry and Longitudinal Relaxation Time of Spontaneously Hypertensive Rats (SHRs) in Early and Intermediate Stages of Hypertension Investigated by 3D VFA-SPGR MRI. Neuroscience 2019, 404:14-26. doi: 10.1016/j.neuroscience.2019.01.030 |
| Berentzen S, Casado-Sainz A, Lange D, Shalgunov V, Tejada IM, Xiong M, L'Estrada ET, Edgar FG, Lee H, Herth MM, Palner M | The chemogenetic receptor ligand clozapine N-oxide induces in vivo neuroreceptor occupancy and reduces striatal glutamate levels. Front Neurosci 2019, 13;187. doi: 10.3389/fnins.2019.00187 |
2018
| Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM | Understanding the role of the perivascular space in cerebral small vessel disease. Cardiovascular research 2018; 114:1462-1473 |
| Lee H, Mortensen K, Sanggaard S, Koch P, Brunner H, Quistorff B, Nedergaard M, Benveniste H | Quantitative Gd-DOTA uptake from cerebrospinal fluid into rat brain using 3D VFA-SPGR at 9.4T. Magn Reson Med 2018; 79:1568-1578 |
2017
| Berentzen S, Casado A, Estrada EL, Edgar FG, Kjaerby C, Lee H, Benveniste H. Herth M, Palner M | In vivo changes in neurotransmitter and metabolite levels following selective activation of the nigrostriatal dopaminergic pathway. JCBFM 2017; 37:221-222 |
| Benveniste H, Lee H, Ding F, Sun Q, Al-Bizri E, Makaryus R, Probst S, Nedergaard M, Stein EA, Lu H | Anesthesia with Dexmedetomidine and Low-dose Isoflurane Increases Solute Transport via the Glymphatic Pathway in Rat Brain When Compared with High-dose Isoflurane. Anesthesiology 2017;127:976-988 |
| Ratner V, Gao Y, Lee H, Elkin R, Nedergaard M, Benveniste H, Tannenbaum A | Cerebrospinal and interstitial fluid transport via the glymphatic pathway modeled by optimal mass transport. Neuroimage 2017;152:530-537 |
2015
| Lee H, Xie L, Yu M, Kang H, Feng T, Deane R, Logan J, Nedergaard M, Benveniste H | The Effect of Body Posture on Brain Glymphatic Transport. J Neurosci 2015;35:11034-44 |
| Makaryus R, Lee H, Feng T, Park JH, Nedergaard M, Jacob Z, Enikolopov G, Benveniste H | Brain maturation in neonatal rodents is impeded by sevoflurane anesthesia. Anesthesiology 2015;123:557-68. |
Ongoing Projects
- Diffusion/Perfusion imaging of awake animals
- Temporal profile of immune cell infiltration following brain infarction
- The role of the glymphatic system in small vessel disease and stroke model
- Glymphatic impairment due to hypertension
- MR Histology (Non-invasive 3D MR-based high-throughput morphological analysis)
- Detection of biomarkers for musculoskeltal disorder animal model
- Early window in acute myocardial infarction using in vivo MR Imaging/Spectroscopy
- In vivo longitudinal measurements of NAA as a neuronal marker in stroke model