Equipment and Facilities

NMR

The Bruker 9.4T NMR instrument was acquired 2012-13 and placed in a new NMR lab in the basement of Building 23 (23.01). The instrument was acquired with funds from the 'National Program for Research Infrastructure', while the Faculty (SUND-KU) financed refurbishment of the 23-01 lab. The 9.4T scanner was fully operational in February 2014, with a wide range of unique accessories, including two advanced cryoprobes (1H and 31P), and a range of coils for both 1H and X-nuclei imaging and spectroscopy.

Bruker Biospec 9.4/30 USR AVANCEIII/MRI

  • 9.4 Tesla (400MHz) Spectrometer
  • 30 cm holizontal bore
  • Active shealded

Gradient Coils

100mT/m 20cm, Max Current = 300A
240mT/m 12cm, Max Current = 300A
1500mT/m 6cm, Max Current = 200A

CryoProbes

400MHz 1H CryoProbe Mouse brain quadrature surface coil Tx/Rx
162MHz 31P CryoProbe For high-sensitive ATP / pH analysis

Ordinary Room-temperature Coils

Double-tuned Surface Coils

19F-1H iD20mm

31P-1H iD20mm

13C-1H iD20mm
Single-tuned Surface Coils

13C/23Na/31P 100-162MHz iD20mm

15N/6Li/2N 40-62MHz iD20mm
Receive-only Coils

1H Rat Heart Array

1H Rat Brain Array

1H Mouse Heart Array

1H Mouse Brain Array

1H Planar Surface iD10mm
Volume Coils

31P/1H iD30mm

1H Rabbit Body iD154mm

1H Rat Body iD86mm

1H Rat Head/Mouse Body iD40mm

1H Mouse Body iD35mm

1H Mouse Head iD23mm

Softwares and Computers

  • ParaVision 5.1 or 6.01 for MRI/MRS acquisition
  • powerful post-processing computers

Animal preparation and physiological monitoring

The NMR facility has an animal preparation room with a surgical setup including:

  • surgical microscope
  • stereotaxic frame
  • heater pad
  • surgical tools
  • separate isoflurane anesthesia setup for induction and surgery.

The facility is equipped with an MR-safe animal physiological monitoring system from SA instruments for

  • monitoring ECG, pulse-oximetry (heart rate, O2 saturation), respiration rate, and temperature during scanning.
  • Water heated beds and tubes are available for maintaining body temperature
  • Isoflurane / Air / O2 / N2 delivery system.

Workshop

The workshop offers technical support and advice in the MRS/MRI prototype development. This includes:

  • Guidance on the selection of experiment, help in setting up experiments, guidance and training of researchers and laboratory staff in carrying out experiments etc.
  • Development and construction of experimental prototypes and equipment for new experiments, including: mechanical prototype development and construction, in the form of metal and plastic machining as turning, milling, drilling, etc., and, 3D printing.
  • Electronic prototype development and construction of any kind from DC to 3GHz, including custom MRS/MRI probes.